Evaluation of acid neutralizing and buffering capacities of selected antacids in Ghana

A recent study in Ghana evaluated the acid neutralizing and buffering capacities (BC) of nine commercial antacid brands (“L1–L9”), all containing aluminum hydroxide and magnesium hydroxide, with 67% also including simethicone. Using standard tests at 37 ± 3 °C, all brands qualified as antacids with preliminary antacid test (PAT) pH above 3.5, and acid neutralizing capacities (ANC) well above the acceptable 5 mEq/g, ranging from 13.16–20.70 mEq/g. Brand L9 showed the highest ANC and superior buffering capacity, while L4 had the lowest ANC and L6 the least buffering. The study found no correlation between cost and efficacy, as both low- and high-priced brands performed within acceptable limits. Researchers recommend that manufacturers display ANC and BC values on product labels to ensure quality, effectiveness, and value for money.