Description
A single 500 mg clotrimazole vaginal pessary was found highly effective in treating vaginal candidiasis during pregnancy, according to a prospective trial involving 46 women in their second and third trimesters. One week after treatment, 83.3% of patients were cured both microscopically and mycologically, and all reported relief of symptoms. The recurrence rate after one month was only 5.7%, and patients who required retreatment responded successfully to a second dose. The study reported no adverse effects and highlighted several benefits of single-dose therapy — effectiveness, safety, rapid symptom relief, high compliance, and low recurrence — making it a simple and reliable option for pregnant patients.