Amlodipine in hypertension: a first-line agent with efficacy for improving blood pressure and patient outcomes

Amlodipine, a widely used calcium channel blocker, shows strong evidence of efficacy and safety in managing high blood pressure and reducing cardiovascular events. Despite the availability of multiple antihypertensive drug classes, blood pressure control remains suboptimal. This review highlights amlodipine’s performance over two decades, backed by large randomized controlled trials. Given its effectiveness in lowering morbidity and mortality, amlodipine should be considered a first-line agent in hypertension treatment.